What Is VDR?

VDR is a gene that encodes for a vitamin D receptor protein. This protein regulates calcium absorption as well as bone development. A variant of the gene, rs2228570 (FokI polymorphism) is associated with reduced bone mineral density in white prepubertal girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by the two components, and is affected by chromosomal positions and binding preferences for certain hormones. Microarray studies of human cells reveal that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) is a repository of information and documents relevant to legal transactions, business or processes. Access to the data, downloading, or printing are not permitted. It is accessed via a central server as well as an extranet connection that is an Internet connection with restricted access to allow controlled access to users at specific times at which users can browse the documents and data.

Investment bankers and companies involved in mergers and acquisitions are the most common users of a VDR. They need to be able to communicate information in a clear manner with potential investors or buyers. The due diligence process can also require a large amount of information. Life science companies also utilize VDRs for everything from clinical trial data to HIPAA compliance documents.


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